Hepatitis B infection caused by the hepatitis B virus (HBV) is life threatening and can infect the liver, causing both acute and chronic disease. According to the WHO, an estimated 257 million people are living with hepatitis B virus infection. While chronic infection can be treated with medicines, including oral antiviral agents, there is no specific treatment for acute hepatitis B. Documentation of hepatitis infection in medical claims must adhere to the guidelines and standards set by concerned insurance companies. Medical coding companies must stay up-to-date with the latest medical billing and coding changes to ensure clean submission of claims.