What Are the ICD-10 Codes for Hypercholesterolemia?

by | Posted: May 26, 2025 | Medical Coding, Medical Billing

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Hypercholesterolemia, classified as a lipid disorder, is characterized by elevated cholesterol levels in the blood. This condition occurs when low-density lipoprotein (LDL), commonly known as “bad cholesterol,” remains excessively high. High LDL levels contribute to fat accumulation in the arteries (atherosclerosis), significantly increasing the risk of heart attacks and strokes. In some cases, an inherited condition leads to exceptionally high cholesterol levels. Without proper treatment, high cholesterol can greatly increase the likelihood of developing heart disease and other cardiovascular complications. For healthcare providers, accurate documentation and precise cholesterol disorders coding is crucial for effective treatment planning and reimbursement. Documentation must provide complete details on patient history, symptoms, clinical findings, diagnostic tests, and treatment plan. Partnering with a reliable medical billing company can ensure accurate code assignment, effective documentation, and clear communication of elevated cholesterol diagnosis.

According to reports, about 1 out of every 20 people has hypercholesterolemia. Nearly 1/3 of American adults have high LDL-C. People are more likely to have a high level of LDL-C if they are older than 40 years. Other risk factors include obesity, smoking, Type 2 diabetes, obstructive liver disease, hypothyroidism, chronic kidney failure and certain genetic changes. High cholesterol doesn’t cause any specific symptoms in most people. However, when the cholesterol level causes the arteries to narrow, then most people have symptoms of heart disease like chest pain, shortness of breath and fatigue.

Understanding ICD-10 Codes for Hypercholesterolemia

ICD-10 coding plays a critical role in accurately documenting medical conditions for insurance claims and billing processes. Hypercholesterolemia is categorized under “Endocrine, nutritional, and metabolic diseases” in ICD-10. These codes help identify the type and cause of hypercholesterolemia, ensuring accurate record-keeping and reimbursement. The specific codes for this condition include –

  • E78 Disorders of lipoprotein metabolism and other lipidemias
  • E78.0 Pure hypercholesterolemia
  • E78.00 …… unspecified
  • E78.01 Familial hypercholesterolemia
  • E78.1 Pure hyperglyceridemia
  • E78.2 Mixed hyperlipidemia
  • E78.4 Other hyperlipidemia
  • E78.41 Elevated Lipoprotein(a)
  • E78.49 Other hyperlipidemia
  • E78.5 Hyperlipidemia, unspecified

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Documentation Guidelines for Hypercholesterolemia

Diagnosis of hypercholesterolemia involves a detailed physical examination. Other diagnosis tests include genetic testing and lipid panel blood test. Treatment for hypercholesterolemia involves bringing down your LDL level to prevent heart disease in different ways such as – exercise, staying at a healthy weight, consuming foods low in saturated fat, taking cholesterol-lowering medications, avoiding tobacco products and controlling high blood pressure and blood sugar. Proper documentation of hypercholesterolemia is essential for accurate diagnosis, effective treatment, and medical billing. Healthcare providers must follow clear and concise guidelines to ensure compliance with regulatory standards and optimize reimbursement.

Here is an overview of documentation best practices for hypercholesterolemia –

  • Specify the Diagnosis – Clearly document the type and cause of hypercholesterolemia. Common subtypes include –
    • Pure Hypercholesterolemia (E78.00) – High cholesterol levels without additional lipid abnormalities.
    • Familial Hypercholesterolemia (E78.01) – An inherited condition causing very high cholesterol levels.

    It is important to ensure that the diagnosis reflects any underlying or contributing conditions, such as diabetes, hypertension, or metabolic syndrome.

    • Include Patient History – Provide a comprehensive medical history that includes –
      • Family History – Note any genetic predisposition to high cholesterol or cardiovascular diseases.
      • Lifestyle Factors – Document dietary habits, physical activity, smoking status, and alcohol consumption.
      • Past Treatments – Record prior interventions, such as lipid-lowering medications or lifestyle modifications.
    • Record Clinical Findings – Accurate documentation should include detailed clinical findings, such as lipid profile results (include total cholesterol, LDL, high-density lipoprotein (HDL), and triglyceride levels), physical exam findings such as xanthomas or corneal arcus, which may indicate familial hypercholesterolemia and cardiovascular risk assessment.
    • Specify Treatment and Management Plans – Clearly outline the proposed treatment plan, including medications, lifestyle modifications (such as recommendations for dietary changes, exercise, and smoking cessation) and follow-up that includes plans for regular monitoring and follow-up visits to assess progress and adjust treatment as necessary.
    • Use ICD-10 Codes Correctly – Accurate coding of cholesterol-related conditions is essential for appropriate reimbursement, patient care continuity, and data integrity. Skilled coders will always choose the most precise code supported by documentation, such as –
      • E78.00 – Pure hypercholesterolemia, unspecified.
      • E78.01 – Familial hypercholesterolemia.

      Link these codes to relevant procedures or treatments to ensure compliance with billing standards.

    • Maintain Compliance with Regulatory Standards – Adhere to HIPAA and other regulations by ensuring patient confidentiality and securing documentation against unauthorized access.
    • Avoid Common Documentation Errors – Avoid common documentation errors like incomplete records like missing lab results, treatment details, or follow-up plans and ambiguous diagnoses and inconsistent updates of patient records.

    Correct ICD-10 coding for hypercholesterolemia is crucial for accurate billing and claim processing. However, it requires expertise to navigate the complexities of selecting the right codes. By outsourcing to professional medical billing and coding services, healthcare providers can ensure accurate coding, reduce administrative burdens, and optimize financial outcomes.

    Expert coders can ensure adherence to ICD-10 guidelines for lipid and cholesterol disorders by accurately interpreting clinical documentation and selecting the most appropriate codes based on specific diagnoses. They stay up to date with the latest coding updates and payer-specific requirements, reducing the risk of denials or audits. Experienced coders also understand the distinctions between related conditions such as hypercholesterolemia (E78.0), familial hypercholesterolemia (E78.01), and mixed hyperlipidemia (E78.2), ensuring precise reporting. Their expertise not only supports proper reimbursement but also promotes accurate record-keeping and better continuity of care.

    Ensure accuracy and compliance in billing and coding!

    Call (800) 670-2809 Today!

    Loralee Kapp

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